|
KMID : 1140120100150020118
|
|
Cancer Prevention Research
2010 Volume.15 No. 2 p.118 ~ p.126
|
|
|
5-Aza-2’-deoxycytidine Induces Cell Cycle Arrest and the Cytoskeletal Reorganization by Recovery of Chimaerin2 in 267B1/K-ras Human Prostate Cancer Cells
|
|
Lim JI-Young
Jeong Sook-Jung
Kim Bo-Yeon
Kim Gun-Do
|
|
|
Abstract
|
|
|
5-Aza-2’-deoxycytidine, a demethylating agent, induced recovery of the expression of tumor suppressor genes. Chimaerin2 among these genes down-regulated the expression of Rac, WAVE2, Arp2/3, and Villin1 in Racdependent
cytoskeletal pathway and led to the changes of cell morphology, actin dynamics and cell migration in 267B1/Kras.
5-Aza-2’-deoxycytidine, also, caused cell cycle arrest at G1 to S phase by the inhibition of the expression of Cyclin-dependent kinases (CDKs), and Cdc25A. The results represent that 5-Aza-2’-deoxycytidine causes cell cycle arrest and regulates Rac-dependent actin polymerization on 267B1/K-ras human prostate cancer cells.
|
|
|
KEYWORD
|
|
|
5-Aza-2’-deoxycytidine, Chimaerin2, Villin1, Cell cycle arrest, Rac
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|